Sister Machine Gun is an American industrial rock band originally based in Chicago, Illinois.

Sister Machine Gun was formed in New York City by Chris Randall and Guilherme Machado. After a short hiatus, the band signed with Wax Trax! Records and released their debut album, Sins of the Flesh, in 1992. The band went through several lineup changes over the years, with their sound evolving throughout their career. After leaving Wax Trax! Records, they moved to Randall's own label, Positron! Records. In 2007, the band disbanded, and Randall pursued a solo career. However, Sister Machine Gun returned in 2015 with a new album The Future Unformed, released on WTII Records.