Karma to Burn is a desert rock / psychedelic rock band from Morgantown, West Virginia founded by guitarist William Mecum, bassist Rich Mullins and drummer Nathan Limbaugh.

The band unofficially disbanded sometime in mid-2002, when bassist Rich Mullins joined Speedealer. As of February 23, 2009, Karma to Burn has reformed and resumed activity.

On April 29, 2021, the last remaining founding member Will Mecum died from injuries sustained from an accidental fall.