Sam Musiker (born 1916, New York City, New York, USA - died 1964) was an American clarinetist and saxophonist (tenor and alto) spanning both jazz and klezmer music. Among the artists that he played with include Gene Krupa's band, Benny Goodman, Roy Eldridge, Anita O’Day and others. He is the brother of Ray Musiker and son-in-law of Dave Tarras.