Active since the early 70s, She was a member of Sugar Babe with Tatsuro Yamashita. In the mid-1970s she began to release solo albums, regularly collaborating with Ryuichi Sakamoto and other members of the Yellow Magic Orchestra. Ohnuki appeared on Sakamoto’s No More Landmine single in 2001 alongside David Sylvian, Cyndi Lauper and UA, and in 2010 released the duo album UTAU and toured with Sakamoto.