US gangsta / Miami Bass rap group from Miami, FL.
Poison Clan was originally a duo made up of JT Money & Debonaire, but the latter left the group after their debut album in 1990, titled 2 Low Life Muthas. He was replaced by Madball & Uzi (who formed the duo Rufftown Mob) & Drugz. Poison Clan released 2 other albums with this line up, entitled Poisonous Mentality (1992) & Rufftown Behavior (1993). Big Ram eventually joined the group for their 4th and last album, Straight Zooism (1995).

In 1995, the group disbanded after JT Money parted ways with Luke Records. JT Money, who was the main performed of Poison Clan, pursued a successful solo career, putting out 4 albums between 1999 & 2005. Madball & Uzi released 2 albums as a duo, including one as Rufftown Mob.