Paul Panhuysen (born August 21, 1934, Borgharen, The Netherlands - died January 29, 2015, Eindhoven, The Netherlands) was a Dutch visual and sound artist.

Panhuysen studied painting and monumental design at the Jan van Eyck Academy in Maastricht and art sociology at the University of Utrecht from 1954 until 1959. He was a director of the Fine Arts Academy in Leeuwarden, a curator for the Den Haag City Museum as well as for the Van Abbe Museum in Eindhoven. In 1965 he founded the artist group De Bende van de Blauwe Hand (Band Of The Blue Hand). This group closely related to Fluxus and presented exhibitions, environments and happenings in museums and galleries.

In 1968, he founded the Maciunas Ensemble and began performing experimental music. Paul Panhuysen had focused on sound art, which was to occupy an important place in his visual art work. He had performed his long string installations during concerts and exhibitions since 1982 in many cities including Boston, Washington D.C., Dresden, Berlin, Hanover, Linz, Ferrara, Barcelona, Lodz, Warsaw, Moscow, Paris, New York, San Francisco, Tokyo, Kobe, Kyoto, Lyon, Rome, Prague and Mexico City. Performances were set up in indoor or outdoor spaces and always took full advantage of site specific sound and architectural properties. In 1980, Paul Panhuysen founded [l281541]: a platform for sound and visual arts, exhibitions and new music concerts. He was the director until its disclosure in 1997.