Eddie Matos grew up in the lower east side of Manhattan. He is of Puerto Rican descent. His interests in music and deejaying came in the late 70's and early 80's. His deejaying influences were Jonathan Fearing, Ted Currier, Shep Pettibone, Tee Scott and Tony Humphries. He was exposed to these DJ's by listening to New York radio stations such as Disco 92, WKTU, WBLS and KISS FM. In 1985 he met John Mateo who had similar music interests. They teamed up and later would be known as Mateo & Matos. That same year he also met Little Louie Vega who played at a club called Heartthrob, formerly the Funhouse (N.Y.C.).

Louie Vega was a big inspiration, he would invite Eddie Matos to studio and editing sessions where he learned about recording, producing and engineering. In 1986 he ventured to David Mancuso's spot, The Loft. In that same year he also was lucky enough to meet the legendary Larry Levan. Listening to these two icons introduced him to the Garage and Loft sounds. From 1986 through 1989, he was heavily into deejaying, from playing in street summer jams to indoor winter jams. Late in 1989 he got into producing and has been producing ever since.